Pioneering innovative therapies to improve the lives of those with genetic intellectual disabilities
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Jérôme Lejeune Foundation
Jérôme Lejeune Foundation
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Grant Recipients
Dr. Emily Brookes Boston, Massachusetts
| 2012 | Elucidating The Role Of Histone Demethylase Smcx In Intellectual Disability Using Human Induced Pluripotent Stem Cells |
Dr. Katheleen GardinerDenver, Colorado Video Interview
| 2012 | Workshop On Cognition In Down Syndrome: Molecular, Cellular And Behavioral Features And The Promise Of Therapeutics | |
| 2011 | Comparative Analysis Of Drug Responses In Mouse Models Of Down Syndrome | |
| 2009 | Aging And Dementia In Down Syndrome: Neuropsychological Profile And Intervention | Down Syndrome, Psychology, Neurology, Dementia, Aging |
| 2009 | Perturbation Of Signaling Pathways In The Tc1 Mouse Model Of Down Syndrome | |
| 2008 | Stabilizing Post Translational Modification (Ptm) In Tissue Samples | |
| 2006 | Conference On The Biology Of Genes On Chromosome 21: Correlation To Gene/phenotype In Trisomy 21 | |
| 2006 | Perturbation Of Signaling Pathways: Application To Cognitive Defects And Trisomy 21 | |
| 2006 | Data Mining For Gene-Phenotype And Drug Response Correlations In Down Syndrome | |
| 2004 | A Database Of Chromosome 21/trisomy 21 | |
| 2002 | Expert Meeting On The Gene-Phenotype Correlations In Trisomy 21 | |
| 2002 | Abnormalities Of The Protein Map Kinase And Calcineurin In Models Of Trisomy 21 Mice | |
| 2000 | Candidate Genes For The Phenotype Of Trisomy 21: Analysis Of Their Expression In The Normal And Trisomic Cell Lines 21 And In Murine Models | |
| 1998 | Analysis Of The Expression Of Known Genes And New Genes In Cell Lines Trisomic And Normal, And Animal Models | Trisomy 21 |
Dr. Aurore Curie Charlestown, Massachusettes
| 2012 | Study Of Neuronal Networks And Cognitive Mechanisms Involved In X Linked Intellectual Disability |
Dr. Kyung-Tai MinBethesda, Maryland
| 2011 | Investigating The Biological Pathways Shared Between Down Syndrome And Fragile X Syndrome | |
| 2005 | Using Drosophila To Study The Etiology Of Alzheimer's Disease In Trisomy 21 |
Prof. Lynn Nadel Tucson, Arizona Profile
| 2011 | High Density EEG Biomakers Of Memory Dysfunction In Down Syndrome | Down Syndrome, Memory, Neurology |
Mr. Mustafa Nazir Okur Chicago, Illinois
| 2011 | ntersectin Regulation Of EGFR Ubiquitylation And Degradation |
Dr. Sarah ElseaRichmond, Virginia
| 2010 | Development And Characterization Of A Neuronal Model System For Analysis Of Compounds To Modulate Rai1 Expression In Smith-Magenis Syndrome | |
| 2008 | Defining The Critical Genes For Disorders Of Behavior And Developmental Delay On Chromosomes 2Q37.3 And 2Q23.1 | |
| 2006 | Identification Of Loci Responsible For Disorders In Mental Retardation Near The Smith-Magenis Syndrome | Smith-Magenis Syndrome |
Dr. Katherina Walz Miami, Florida Profile
| 2010 | Exploring The Reversibility Of Neuron Functional Deficiency |
Dr. Juan Young Miami, Florida Profile
| 2010 | Modulation Of Rett-Like Phenotypes In Mouse Models Of Rett Syndrome |
Prof. Randal Roper Indianapolis, Indiana Profile
| 2010 | Mechanisms Of Craniofacial And Appendicular Bone Development Disrupted By Trisomy In Down Syndrome |
Dr. Dana Crawford Albany, New York Profile
| 2009 | The Role And Targeting Of Rcan1 In Down Syndrome | |
| 2004 | Involvement Of Neuronal Overexpression Of The Gene adapt78 (DSCR1) In Trisomy 21 |
Dr. Gilbert Di PaoloNew York, New York Profile Video Interview
| 2009 | Lipid Imbalance And Endosomal Dysfunction In Down Syndrome: A Lipidomic Approach | |
| 2006 | Role Of The Over-Expression Of Synj1 In Cognitive Deficits In Mouse Models For Trisomy 21 | |
| 2002 | Study Of The Metabolism Of Pip2 In A Mouse Model Of Trisomy 21 |
Dr. Xiaolu Sturgeon Aurora, Colorado
| 2009 | Down Syndrome And Intellectual Disability Gene Networks |
Dr. Edwin J. Weeber Tampa, Florida Profile Website
| 2009 | The rapeutic Interventions For Angelman Syndrome |
Ms. Janet L. Hauck Ann Arbor, Michigan Profile
| 2009 | Promoting Physical Activity In Young Children With Down Syndrome |
Prof. Jan Peter Kraus Aurora, Colorado Profile Articles
| 2009 | Targeting Misfolding In Homocystinuria | |
| 2006 | Cbs: A Key Enzyme Involved In Homocysteine Metabolism And Hydrogen Sulfide | |
| 2004 | Mouse Models Of Deficiency Homocystinuria Cystathionine Beta Synthase (Cbs) |
Dr. John O'Bryan Chicago, Illinois Profile
| 2008 | Defining Intersectin (ITSN) Function In Down Syndrome |
Dr. Jianhua Wu Atlanta, Georgia
| 2008 | Effect Of Ankle Weights On Overground Walking In Preadolescents With And Without Down Syndrome |
Dr. Shannon Ringenbach Tempe, Arizona Profile
| 2008 | Examination Of Intra And Interhemispheric Processing Following Different Instructiong During Long Term Motor Learning In Persons With Down Syndrome | |
| 2006 | Music And Movement In Persons With Down Syndrome |
Dr. Heather LehmanBuffalo, New York Profile
| 2008 | Humoral Immunodeficiency In Pediatric Down Syndrome Patients |
Dr. Kenneth Maclean Aurora, Colorado
| 2008 | Novel Pathogenic Mechanisms And Treatment For Cognitive Impairment In Cbs Deficient Homocystinuria |
Dr. Sandra Ryeom Boston, Massachussetts
| 2008 | Down Syndrome: Protection Against Cancer And The Role Of The Down Syndrome Candidate Region-1 Gene |
Ms. Ann C.M. Smith Bethesda, Maryland
| 2007 | Comparative Behavioral Phenomics: Investigation Of Structural And Functional Brain Networks In Smith-Magenis Syndrome And Relat |
Dr. Maria Tejada-Simon Houston, Texas Profile
| 2007 | Therapeutic Potential Of Rac1 Inhibitors In Cognitive Disorders |
Ms. Katy Wong Chicago, Illinois
| 2007 | The Regulation Of Receptor Tyrosine Kinase Trafficking By Intersectin |
Dr. H.Graig HellerStanford, California
| 2007 | GABA Based Pharmacotherapy Essays For Improving Cognition Through The Consolidation Of Sleep And Wake In Ts65Dn Mice |
Dr. Gene Fisch New York, New York Profile
| 2007 | Longitudinal Studies Of Children With Subtelomeric Deletions Causing Mental Handicap | |
| 2005 | Longitudinal studies of subtelomeric deletions cause of mental disability |
Dr. Anita Bhattacharyya Madison, Wisconsin Profile
| 2007 | Generation Of Human Trisomy 21 Pluripotent Cells |
Dr. Eugene YuBuffalo, New York Profile
| 2007 | Effects Of Human Chromosome 21 Synthetic Regions And Dyrk1 On Trisomy 21-Related Phenotypes In Mice | |
| 2005 | Characterization Of New Mouse Models Of Trisomy 21 Chromosomes Developed By Engineering |
Dr. Jennifer Vannest Cincinnati, Ohio Profile
| 2006 | The Neural Basis Of Language In Neurodevelopmental Disorders | Neurology, Linguistics |
Dr. Yu-Wen Hwang Staten Island, New York
| 2006 | Regulation Of The Assembly Of Endocytic Complex By Dyrk1A |
Dr. Alberto CostaDenver, Colorado Article
| 2006 | Preclinical Development Of Targeted Pharmacotherapy At Associated Hypomyelination To Down Syndrome |
Dr. Jean-Bernard ManentStorrs, Connecticut
| 2006 | Investigating The Reversibility Of Neuronal Migration Disorders In Animal Model Year Of Double Cortex Syndrome |
Dr. Michael Miles Cincinnati, Ohio Profile
| 2005 | Evaluation Of Effectiveness Of Coenzyme Q10 (uniquinone) In Children With Trisomy 21 |
Dr. David Patterson Denver, Colorado Profile
| 2005 | Mouse Models Over-Expressing Or Knockout The Gene Of The Reduced Folate Carrier (Rfc): Study Of The Role Of Rfc In Trisomy 21 | |
| 2003 | Production And Use Of Transgenic Mice Cbs To Understand The Role Of This Enzyme In Trisomy 21 | |
| 2002 | Study Of Mitochondrial Proteins During Therapeutic Interventions In A Mouse Model Of Trisomy 21 | |
| 2002 | Role Of Mitochondrial Proteins And Metabolic Response In The Mouse Model Ts65Dn Trisomy 21 | |
| 2001 | Effect Of A Diet Rich In Antioxidants To Prevent The Loss Of Cholinergic Neurons And Cognitive Decline In Mice | |
| 1999 | Study Of The Variation In Purine Diet And Folate On A Mouse Model Of Trisomy 21 |
Dr. Zygmunt Galdzicki Bethesda, Maryland
| 2004 | Signaling Pathways In Platelets Of Patients And Mouse Models Of Trisomy 21 | |
| 2001 | The Impact Of Kainate Receptor Over-Expression On Brain And Spinal Cord Synaptic Plasticity In Mouse Ts65Dn - Animal Model Of Down Syndrome |
Prof. Emmanuel Mignot Palo Alto, California Profile
| 2003 | The Cycle Of Sleep In A Model Of Trisomy 21: Metabolic Implications |
Prof. Paul Yarowsky Baltimore, Maryland Profile
| 2003 | Proliferation And Survival Of Neural Stem Cells Adult Ts65Dn Mice | |
| 2001 | Manipulation Of Adult Neurogenesis In Mice Ts65Dn, A Model Of Down Syndrome |
Mr. Tyler Best Bethesda, Maryland
| 2003 | Pip2 Modulation Of Channel Current Girk In Trisomy 21 |
Prof. Mark Schapiro Cincinnati, Ohio
| 2002 | Study Of Language Processing By Functional Magnetic Resonance Imaging In Individuals With Trisomy 21 |
Pioneering innovative therapies to improve the lives of those with genetic intellectual disabilities
Blog Updates
Lejeune In the News
The Fork in the Road, Joseph Dutkowsky, MD
Thursday, September 11, 2014 - 17:09
Improving Joyful Lives. A new paper on Down syndrome prepared by the Jerome Lejeune Foundation
Monday, July 28, 2014 - 11:25
Jerome Lejeune Foundation at the Supreme Court
Friday, June 13, 2014 - 02:52
A Saint for the Cause of Life: Jerome Lejeune
Friday, June 13, 2014 - 02:52
World Down Syndrome Day and 20 Week Laws
Friday, June 13, 2014 - 02:51
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About Jérôme Lejeune Foundation USA
The Jerome Lejeune Foundation (France and the U.S.) was founded in 1996 to carry on the work of the legendary geneticist, Jerome Lejeune. Through its mission of research, care, and advocacy, the Jerome Lejeune Foundation serves those with Down syndrome and other genetic intellectual disabilities in a spirit of profound respect for their inherent human dignity, and that of all human persons.
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